Table 1 Comparison between results of NIPS with and without cffDNA enrichment on 1404 clinical samples
Method | NIPS without cffDNA enrichment | NIPS with cffDNA enrichment |
|---|---|---|
Total | 1404 | 1404 |
Test failure | 10 (0.7%) | 1 (0.1%) |
Test positive | 8 | 10 |
True positive | 5 | 5 |
Test negative | 1394 | 1394 |
True negative | 1397 | 1399 |
Sensitivity | 100% 95% CI (56.55–100) | 100% 95% CI (56.55–100) |
Specificity | 99.79% 95% CI (99.37–99.93) | 99.64% 95% CI (99.17–99.85) |
PPV | 62.50% 95% CI (30.6–86.3) | 50% 95% CI (23.7–76.3) |
NPV | 100% 95% CI (99.73–100) | 100% 95% CI (99.73–100) |