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Table 6 Associations between the biochemical analyses of liver tissue content and the histopathological findings

From: Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: consequences of high fat-fructose-cholesterol diet and diabetes

Variable

Triglycerides^

Cholesterol^

Glycogen^

Parametric findings

 ORO-VIS (lipid)

< 0.0001 (0.59)a

0.0004 (0.27)a

0.0001 (0.32)a

 PSR-VIS (collagen)

0.4 (0.04)

< 0.0001 (0.34)a

0.6 (0.01)

 Iba1-VIS (inflammation)

0.3 (0.03)

< 0.0001 (0.39)a

0.9 (0.001)

Categorical scores

 Steatosis

0.006 (0.17)a

0.004 (0.24)a

0.1 (0.09)

 Fibrosis

0.4 (0.07)

0.006 (0.27)a

0.6 (0.05)

 Inflammation

0.3 (0.1)

0.0002 (0.39)a

0.9 (0.01)

 Cytoplasmic alterations

0.98 (0.00)

< 0.0001 (0.73)a

0.2 (0.11)

 PAS positive

0.005 (0.29)a

0.4 (0.07)

< 0.0001 (0.75)a

  1. Iba1-VIS quantification of macrophages on Iba1 immunohistochemical stain, ORO-VIS quantification of lipid on oil red O stain, PAS positive periodic acid Schiff stain for glycogen, PSR-VIS quantification of collagen on picro-sirius red stain
  2. Data presented as p-value (R2)
  3. ^Transformed
  4. aSignificant result