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Table 1 Patient characteristics with respect to PCDH17 expression

From: Reduced protocadherin17 expression in leukemia stem cells: the clinical and biological effect in acute myeloid leukemia

Patient characteristics

AML (TCGA dataset)

High PCDH17 (n = 86)

Low PCDH17 (n = 87)

P

Age, years

0.41

 Median

59

57

 Range

18–88

21–82

Sex (male/female)

54/32

38/49

0.01

WBC count, × 109/L

< 0.0001

 Median

9.3

34

 Range

0.4–116.2

0.8–297.4

BM blasts, %

0.04

 Median

68.5

75

 Range

30–100

32–100

PB blasts, %

< 0.001

 Median

18

49

 Range

0–97

0–98

Karyotype

0.343

 Favorable

16

16

 Intermediate

46

55

 Adverse

23

14

 Unknown

1

2

FLT3-ITD

0.002

 Present

6

21

 Absent

80

66

NPM1

0.02

 Mutated

17

31

 Wild-type

69

56

CEBPA

1

 Single mutated

4

4

 Double mutated

2

3

 Wild-type

80

80

IDH1

0.28

 Mutated

10

6

 Wild-type

76

81

IDH2

0.82

 Mutated

8

9

 Wild-type

78

78

RUNX1

0.769

 Mutated

8

7

 Wild-type

78

80

DNMT3A

0.755

 Mutated

20

22

 Wild-type

66

65

TP53

0.005

 Mutated

12

2

 Wild-type

74

85

ERG expressiona

0.08

 High

37

49

 Low

49

38

BAALC expressiona

0.494

 High

45

41

 Low

41

46

MN1 expressiona

0.704

 High

44

42

 Low

42

45

WT1 expressiona

0.323

 High

40

47

 Low

46

40

  1. AML acute myeloid leukemia, TCGA The Cancer Genome Atlas, WBC white blood cells, BM bone marrow, PB peripheral blood, ITD internal tandem duplication
  2. aThe median expression value was used as a cut point