Key metabolic parameters change significantly in early breast cancer survivors: an explorative PILOT study

Table 3 Metabolic profile and females sex hormones of postmenopausal patients at baseline (T0) compared to postmenopausal healthy controls

	Premenopausal controls (n = 21)	Premenopausal BC patients (T0) (n = 20)	P-value^c
BMI (kg/m²)^b	*26.2* [23.1; 28.2]	*26.3* [22.7; 30.8]	0.6
Waist (cm)^a	*89.0* ± 10.3	*88.7* ± 11.1^e	1.0
Body fat (%)^a	*38.1* ± 6.57	*38.5* ± 5.77	0.8
Lean body mass (kg)^a	*42.5* ± 6.18	*43.5* ± 6.13	0.6
Bone mineral density (g/cm²)	*1.06* ± 0.08^f	*1.08* ± 0.11	0.6
Total cholesterol (mmol/L)	*5.72* ± 0.89	*5.56* ± 0.83	0.5
LDL (mmol/L)^a	*3.39* ± 0.76	*3.27* ± 0.90	0.6
HDL (mmol/L)^a	*1.81* ± 0.49	*1.73* ± 0.52	0.6
Triglyceride (mmol/L)^b	*1.1* [0.9; 1.2]	*1.15* [0.9; 1.2]	0.6
Glucose (mmol/L)^a	*5.6* ± 0.74	*5.9* ± 0.61	0.2
Insulin (pmol/L)^b	*37.3* [28.2; 49.3]	*41.1* [32.0; 52.8]	0.6
HbA1c (mmol/mol)^a	*38.8* ± 3.43	*37.0* ± 4.64	0.2
Systolic blood pressure (mmHg)	*117* ± 12.1	*119* ± 11.3	0.7
Diastolic blood pressure (mmHg)	*74.5* ± 7.19	*72.4* ± 5.87	0.3
Hs-CRP (mg/L)^b	*0.93* [0.6; 1.77]	*1.43* [0.76; 3.9]	0.06
CD163 (mg/L)	*1.77* [1.58; 2.16]	*1.93* [1.77; 2.08]	0.3
CD206 (mg/L)	*0.22* [0.17; 0.26]	*0.23* [0.18; 0.29]	0.5
MetS^g	*3 (14%)*	*5 (25%)*	0.4 ^d
FSH (IU/L)	78 [57.8; 92]	*74.5* [62.2; 98.4]	0.7
LH (IU/L)	39 [27.9; 49.1]	*41.5* [36; 44.9]	1.0
Estradiol (pmol/L)	16 [15; 27.4]	15 [15; 22.7]	0.6

The italic values reflect P-values, and the bolditalic values reflects means/medians
BMI body mass index, LDL low-density lipoprotein, HDL high-density lipoprotein, HbA1c hemoglobin A1c, Hs-CRP high sensitivity C-reactive protein, MetS metabolic syndrome, FSH follicle- stimulating hormone, LH luteinizing hormone
* Statistical significant
^aMean
^bMedian
^cTwo sample T-test for means and Wilcoxon rank sum test for medians
^dPearson chi² test
^en = 17
^fn = 20
^gAt least 3 of the following 5: HDL < 1.3, triglycerides ≥ 1.7, waistline > 88 cm, fasting glucose ≥ 6.1, blood pressure ≥ 130/85

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