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Table 4 Comparison of CR rate among genotypes after two courses of Ara-C based chemotherapy

From: Genetic polymorphisms of histone methyltransferase SETD2 predicts prognosis and chemotherapy response in Chinese acute myeloid leukemia patients

Genotype Total (n) CR (n, %) Non-CR (n, %) OR (95% CI) p OR (95% CI)a pa
rs4082155
 AA 157 96 (61.1%) 61 (38.9%) 1.00 (reference)   1.00 (reference)  
 AG 266 184 (69.2%) 82 (30.8%) 0.701 (0.464–1.060) 0.092 0.562 (0.340–0.931) 0.025*
 GG 123 88 (71.5%) 35 (28.5%) 0.626 (0.377–1.039) 0.07 0.501 (0.265–0.946) 0.033*
 AA 157 96 (61.1%) 61 (38.9%) 1.00 (reference)   1.00 (reference)  
 AG + GG 389 272 (69.9%) 117 (30.1%) 0.677 (0.460–0.997) 0.048* 0.544 (0.338–0.876) 0.012*
rs6767907
 GG 237 155 (65.4%) 82 (34.6%) 1.00 (reference)   1.00 (reference)  
 GA 242 171 (70.7%) 71 (29.3%) 0.698 (0.396–1.230) 0.213 0.668 (0.323–1.379) 0.275
 AA 67 42 (62.7%) 25 (37.3%) 0.889 (0.506–1.560) 0.681 1.126 (0.548–2.317) 0.746
rs76208147
 CC 422 273 (64.7%) 149 (35.3%) 1.00 (reference)   1.00 (reference)  
 CT 110 84 (76.4%) 26 (23.6%) 0.567 (0.350–0.919) 0.021* 0.600 (0.342–1.053) 0.075
 TT 14 11 (78.6%) 3 (21.2%) 0.500 (0.137–1.819) 0.293 0.545 (0.114–2.604) 0.447
  1. *p < 0.05
  2. a Adjusted for age, risk stratification, LDH and WBC