Genetic polymorphisms of histone methyltransferase SETD2 predicts prognosis and chemotherapy response in Chinese acute myeloid leukemia patients

Table 3 Univariate and multivariate Cox regression analysis of SNPs associated with AML overall survival (OS)

Genotype	n	Mean ± SE (day)	Median (range, day)	HR (95% CI)	p	HR (95% CI)^a	p ^a
rs4082155
AA	148	1897 ± 293	926 (663–1189)	1.00 (reference)
AG	262	1264 ± 81	721 (478–964)	1.148 (0.867–1.520)	0.335	1.074 (0.797–1.447)	0.638
GG	120	1300 ± 114	1015 (599–1431)	1.014 (0.724–1.420)	0.989	0.989 (0.690–1.418)	0.953
rs6767907
GG	65	1717 ± 224	817 (608–1026)	1.00 (reference)
GA	236	1319 ± 85	735 (356–1114)	0.913 (0.714–1.167)	0.466	1.243 (0.882–1.880)	0.302
AA	229	1338 ± 162	1137 (411–1862)	1.047 (0.880–1.246)	0.602	1.261 (0.833–1.910)	0.273
rs76208147
CC	406	1844 ± 195	817 (563–1071)	1.00 (reference)
CT	109	1175 ± 101	1000 (697–1302)	1.001 (0.751–1.334)	0.995	1.131 (0.83–1.54)	0.428
TT	15	601 ± 146	395 (71–718)	1.836 (1.001–3.369)	0.049*	1.736 (0.84–3.58)	0.135
CC + CT	515	1806 ± 182	885 (697–1073)			1.00 (reference)
TT	15	601 ± 146	395 (71–718)	1.838 (1.005–3.360)	0.048*	1.923 (1.007–3.675)	0.048*

ISSN: 1479-5876