Skip to main content

Advertisement

Table 3 Univariate and multivariate Cox regression analysis of SNPs associated with AML overall survival (OS)

From: Genetic polymorphisms of histone methyltransferase SETD2 predicts prognosis and chemotherapy response in Chinese acute myeloid leukemia patients

Genotype n Mean ± SE (day) Median (range, day) HR (95% CI) p HR (95% CI)a p a
rs4082155
 AA 148 1897 ± 293 926 (663–1189) 1.00 (reference)    
 AG 262 1264 ± 81 721 (478–964) 1.148 (0.867–1.520) 0.335 1.074 (0.797–1.447) 0.638
 GG 120 1300 ± 114 1015 (599–1431) 1.014 (0.724–1.420) 0.989 0.989 (0.690–1.418) 0.953
rs6767907
 GG 65 1717 ± 224 817 (608–1026) 1.00 (reference)    
 GA 236 1319 ± 85 735 (356–1114) 0.913 (0.714–1.167) 0.466 1.243 (0.882–1.880) 0.302
 AA 229 1338 ± 162 1137 (411–1862) 1.047 (0.880–1.246) 0.602 1.261 (0.833–1.910) 0.273
rs76208147
 CC 406 1844 ± 195 817 (563–1071) 1.00 (reference)    
 CT 109 1175 ± 101 1000 (697–1302) 1.001 (0.751–1.334) 0.995 1.131 (0.83–1.54) 0.428
 TT 15 601 ± 146 395 (71–718) 1.836 (1.001–3.369) 0.049* 1.736 (0.84–3.58) 0.135
 CC + CT 515 1806 ± 182 885 (697–1073)    1.00 (reference)  
 TT 15 601 ± 146 395 (71–718) 1.838 (1.005–3.360) 0.048* 1.923 (1.007–3.675) 0.048*
  1. *p < 0.05
  2. a Adjusted for risk stratification, age, allo-SCT, WBC count and LDH count