Table 2 Performance parameters for discriminating among Seminomas and Non-Seminomatous Tumors
Gene/panel | AUC (95% CI) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) |
|---|---|---|---|---|---|---|
VIRMA | 0.85 (0.79–0.90) | 77.3 | 81.1 | 72.0 | 86.1 | 80.2 |
YTHDF3 | 0.64 (0.55–0.72) | 53.3 | 81.1 | 63.5 | 73.9 | 70.6 |
VIRMA/YTHDF3 (≥ 1 above cutoff) | – | 82.7 | 72.1 | 64.6 | 87.1 | 76.1 |
VIRMA/YTHDF3 (both above cutoff) | – | 48.0 | 90.2 | 75.0 | 73.8 | 74.1 |