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Table 2 Performance parameters for discriminating among Seminomas and Non-Seminomatous Tumors

From: m6A RNA modification and its writer/reader VIRMA/YTHDF3 in testicular germ cell tumors: a role in seminoma phenotype maintenance

Gene/panel AUC
(95% CI)
Sensitivity (%) Specificity (%) PPV (%) NPV (%) Accuracy (%)
VIRMA 0.85 (0.79–0.90) 77.3 81.1 72.0 86.1 80.2
YTHDF3 0.64 (0.55–0.72) 53.3 81.1 63.5 73.9 70.6
VIRMA/YTHDF3
(≥ 1 above cutoff)
82.7 72.1 64.6 87.1 76.1
VIRMA/YTHDF3
(both above cutoff)
48.0 90.2 75.0 73.8 74.1
  1. AUC area under the curve, CI confidence interval, PPV positive predictive value; NPV negative predictive value