From: Adiponectin regulates bone mass in AIS osteopenia via RANKL/OPG and IL6 pathway
Single nucleotide polymorphism (associate gene) | Group A (AIS osteopenia) | Group B (AIS normal bone mass) | Group C (control) | p_{A–B–C} | p_{A–B} | p_{A–C} | p_{B–C} |
---|---|---|---|---|---|---|---|
Number (%) | Number (%) | Number (%) | |||||
rs7639352 (ADIPOQ) | |||||||
C/C | 65 (32.5%) | 95 (45.5%) | 118 (57.3%) | < 0.05 | 0.006 | < 0.0167 | 0.032 |
T/T | 32 (16%) | 17 (8.1%) | 18 (8.7%) | ||||
C/T | 103 (51.5%) | 97 (46.4%) | 70 (34%) | ||||
Allele | |||||||
C | 233 (58.25%) | 287 (68.7%) | 306 (74.3%) | < 0.05 | 0.002 | < 0.0167 | 0.074 |
T | 167 (41.75%) | 131 (31.3%) | 106 (25.7%) | ||||
rs10937273 (ADIPOQ) | |||||||
G/G | 72 (36%) | 70 (33.5%) | 72 (35%) | 0.957 | |||
A/A | 33 (16.5%) | 33 (15.8%) | 36 (17.5%) | ||||
G/A | 95 (47.5%) | 106 (50.7%) | 98 (47.6%) | ||||
rs1648707 (ADIPOQ) | |||||||
C/C | 50 (25%) | 42 (20.1%) | 48 (23.3%) | 0.588 | |||
A/A | 51 (25.5%) | 62 (29.7%) | 64 (31.1%) | ||||
C/A | 99 (49.5%) | 105 (50.2%) | 94 (45.6%) | ||||
rs266719 (ADIPOQ) | |||||||
C/C | 154 (77%) | 167 (79.9%) | 156 (75.7%) | 0.355 | |||
T/T | 3 (1.5%) | 2 (1%) | 0 (0%) | ||||
C/T | 43 (21.5%) | 40 (19.1%) | 50 (24.3%) | ||||
rs822354 (ADIPOQ) | |||||||
G/G | 150 (75%) | 150 (71.8%) | 140 (68%) | 0.585 | |||
A/A | 3 (1.5%) | 5 (2.4%) | 4 (1.9%) | ||||
G/A | 47 (23.5%) | 54 (25.8%) | 62 (30.1%) | ||||
rs822387 (ADIPOQ) | |||||||
T/T | 199 (99.5%) | 208 (99.5%) | 206 (100%) | 0.603 | |||
C/T | 1 (0.5%) | 1 (0.5%) | 0 | ||||
rs17300539 (ADIPOQ) | |||||||
G/G | 200 (100%) | 209 (100%) | 206 (100%) | 1 | |||
rs12342 (ADIPOQ RECEPTOR 2) | |||||||
C/C | 51 (25.5%) | 45 (21.5%) | 56 (27.2%) | 0.236 | |||
T/T | 43 (21.5%) | 61 (29.2%) | 58 (28.2%) | ||||
C/T | 106 (53%) | 103 (49.3%) | 92 (44.7%) | ||||
rs11642015 (FTO) | |||||||
C/C | 156 (78%) | 159 (76.1%) | 150 (72.8%) | 0.801 | |||
T/T | 4 (2%) | 4 (1.9%) | 4 (1.9%) | ||||
C/T | 40 (20%) | 46 (22%) | 52 (25.2%) |