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Table 1 Inclusion and exclusion criteria according to the study protocol

From: Saliva molecular inflammatory profiling in female migraine patients responsive to adjunctive cervical non-invasive vagus nerve stimulation: the MOXY Study

Inclusion criteria Exclusion criteria
Chronic refractory headache disorder according to the International Classification of Headache Disorders ICHD (third edition; beta)
Age equal/greater 18
Informed consent (Study, nVNS)
Refractory to medical and/or behavioural therapy
Medication overuse headache has been ruled out
Eligible for vagus nerve stimulation
Willingness to a defined follow-up interval
Intracranial and cervical pathologies excluded by MR scan
Standard medication 4 weeks prior to nVNS and within the entire study period according to the individual’s prescriptions
No informed consent
Other concomitant neuropsychiatric comorbidity not adequate classified and/or requiring specific diagnosis or treatment
Pregnancy
Malignancy
Previous performed invasive, noninvasive and ablative procedure
Not willing to complete pain diary regarding severity and frequency