Inclusion criteria | Exclusion criteria |
---|---|
Chronic refractory headache disorder according to the International Classification of Headache Disorders ICHD (third edition; beta) Age equal/greater 18 Informed consent (Study, nVNS) Refractory to medical and/or behavioural therapy Medication overuse headache has been ruled out Eligible for vagus nerve stimulation Willingness to a defined follow-up interval Intracranial and cervical pathologies excluded by MR scan Standard medication 4 weeks prior to nVNS and within the entire study period according to the individual’s prescriptions | No informed consent Other concomitant neuropsychiatric comorbidity not adequate classified and/or requiring specific diagnosis or treatment Pregnancy Malignancy Previous performed invasive, noninvasive and ablative procedure Not willing to complete pain diary regarding severity and frequency |