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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: A two-circular RNA signature as a noninvasive diagnostic biomarker for lung adenocarcinoma

Fig. 5

Hsa_circ_0005962 promotes LUAD cell proliferation in vitro. a Hsa_circ_0005962 expression was upregulated in the LUAD cells (A549, H1299 and HCC827) compared to that of the normal human bronchial epithelial cells (16HBE). b Hsa_circ_0086414 was downregulated in the LUAD cells compared to that of the 16HBE cells and was differentially expressed between the LUAD cells with (HCC827) and without (A549 and H1299) EGFR mutations. c qRT-PCR analysis of hsa_circ_0005962 expression in A549 and H1299 cells after transfection with a specifically synthesized siRNA. d The CCK-8 assay showed that hsa_circ_0005962 promoted A549 and H1299 cell proliferation. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001

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