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Table 2 Incidence density rates and hazard ratios of chronic fatigue syndrome according to inflammatory bowel disease status stratified by sex, age, and comorbidity

From: Increased risk of chronic fatigue syndrome in patients with inflammatory bowel disease: a population-based retrospective cohort study

Variables

IBD

Compared to the non-IBD group

No

Yes

HR (95% CI)

Event no.

Person-year

IR

Event no.

Person-year

IR

Crude

Adjusteda

Overall

128

53,457

2.39

81

13,411

6.04

2.52 (1.91–3.33)***

2.25 (1.70–2.99)***

Sex

 Women

81

28,667

2.83

37

7201

5.14

1.82 (1.23–2.68)**

1.67 (1.13–2.48)*

 Men

47

24,790

1.90

44

6210

7.09

3.73 (2.47–5.63)***

3.23 (2.12–4.91)***

Age, years

 20–34

23

14,322

1.61

11

3620

3.04

1.91 (0.93–3.92)

1.83 (0.89–3.78)

 35–49

33

17,852

1.85

25

4490

5.57

3.01 (1.79–5.06)***

2.65 (1.56–4.50)***

 50–64

41

13,046

3.14

22

3261

6.75

2.15 (1.28–3.60)**

1.81 (1.06–3.07)*

 ≥ 65

31

8237

3.76

23

2040

11.27

2.97 (1.73–5.09)***

2.79 (1.62–4.82)***

Comorbidity statusb

 No

62

38,739

1.60

32

8174

3.91

2.43 (1.59–3.73)***

2.50 (1.63–3.84)***

 Yes

66

14,718

4.48

49

5237

9.36

2.09 (1.44–3.02)***

2.11 (1.46–3.05)***

  1. IBD inflammatory bowel disease, IR incidence density rate, per 1000 person-years, HR hazard ratio, CI confidence interval
  2. * P < 0.05, ** P < 0.01, *** P < 0.001
  3. aModel mutually adjusted for age, cancer, diabetes, obesity, depression, anxiety, sleep disorder, and renal disease
  4. bPatients with any one of cancers, diabetes, obesity, depression, anxiety, sleep disorder, and renal disease were classified as the comorbidity group
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Journal of Translational Medicine

ISSN: 1479-5876

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