|
Variables
|
IBD
|
Compared to the non-IBD group
|
|---|
|
No
|
Yes
|
HR (95% CI)
|
|---|
|
Event no.
|
Person-year
|
IR
|
Event no.
|
Person-year
|
IR
|
Crude
|
Adjusteda
|
|---|
|
Overall
|
128
|
53,457
|
2.39
|
81
|
13,411
|
6.04
|
2.52 (1.91–3.33)***
|
2.25 (1.70–2.99)***
|
|
Sex
|
|
Women
|
81
|
28,667
|
2.83
|
37
|
7201
|
5.14
|
1.82 (1.23–2.68)**
|
1.67 (1.13–2.48)*
|
|
Men
|
47
|
24,790
|
1.90
|
44
|
6210
|
7.09
|
3.73 (2.47–5.63)***
|
3.23 (2.12–4.91)***
|
|
Age, years
|
|
20–34
|
23
|
14,322
|
1.61
|
11
|
3620
|
3.04
|
1.91 (0.93–3.92)
|
1.83 (0.89–3.78)
|
|
35–49
|
33
|
17,852
|
1.85
|
25
|
4490
|
5.57
|
3.01 (1.79–5.06)***
|
2.65 (1.56–4.50)***
|
|
50–64
|
41
|
13,046
|
3.14
|
22
|
3261
|
6.75
|
2.15 (1.28–3.60)**
|
1.81 (1.06–3.07)*
|
|
≥ 65
|
31
|
8237
|
3.76
|
23
|
2040
|
11.27
|
2.97 (1.73–5.09)***
|
2.79 (1.62–4.82)***
|
|
Comorbidity statusb
|
|
No
|
62
|
38,739
|
1.60
|
32
|
8174
|
3.91
|
2.43 (1.59–3.73)***
|
2.50 (1.63–3.84)***
|
|
Yes
|
66
|
14,718
|
4.48
|
49
|
5237
|
9.36
|
2.09 (1.44–3.02)***
|
2.11 (1.46–3.05)***
|
- IBD inflammatory bowel disease, IR incidence density rate, per 1000 person-years, HR hazard ratio, CI confidence interval
- * P < 0.05, ** P < 0.01, *** P < 0.001
- aModel mutually adjusted for age, cancer, diabetes, obesity, depression, anxiety, sleep disorder, and renal disease
- bPatients with any one of cancers, diabetes, obesity, depression, anxiety, sleep disorder, and renal disease were classified as the comorbidity group
