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Table 2 Incidence density rates and hazard ratios of chronic fatigue syndrome according to inflammatory bowel disease status stratified by sex, age, and comorbidity

From: Increased risk of chronic fatigue syndrome in patients with inflammatory bowel disease: a population-based retrospective cohort study

Variables IBD Compared to the non-IBD group
No Yes HR (95% CI)
Event no. Person-year IR Event no. Person-year IR Crude Adjusteda
Overall 128 53,457 2.39 81 13,411 6.04 2.52 (1.91–3.33)*** 2.25 (1.70–2.99)***
Sex
 Women 81 28,667 2.83 37 7201 5.14 1.82 (1.23–2.68)** 1.67 (1.13–2.48)*
 Men 47 24,790 1.90 44 6210 7.09 3.73 (2.47–5.63)*** 3.23 (2.12–4.91)***
Age, years
 20–34 23 14,322 1.61 11 3620 3.04 1.91 (0.93–3.92) 1.83 (0.89–3.78)
 35–49 33 17,852 1.85 25 4490 5.57 3.01 (1.79–5.06)*** 2.65 (1.56–4.50)***
 50–64 41 13,046 3.14 22 3261 6.75 2.15 (1.28–3.60)** 1.81 (1.06–3.07)*
 ≥ 65 31 8237 3.76 23 2040 11.27 2.97 (1.73–5.09)*** 2.79 (1.62–4.82)***
Comorbidity statusb
 No 62 38,739 1.60 32 8174 3.91 2.43 (1.59–3.73)*** 2.50 (1.63–3.84)***
 Yes 66 14,718 4.48 49 5237 9.36 2.09 (1.44–3.02)*** 2.11 (1.46–3.05)***
  1. IBD inflammatory bowel disease, IR incidence density rate, per 1000 person-years, HR hazard ratio, CI confidence interval
  2. * P < 0.05, ** P < 0.01, *** P < 0.001
  3. aModel mutually adjusted for age, cancer, diabetes, obesity, depression, anxiety, sleep disorder, and renal disease
  4. bPatients with any one of cancers, diabetes, obesity, depression, anxiety, sleep disorder, and renal disease were classified as the comorbidity group