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Table 2 Cox proportional hazards ratio model of primary outcomes

From: New risk score for predicting progression of membranous nephropathy

  Univariate analysis HR (95% CI) P Multivariate analysis HR (95% CI) P HR (95% CI) from Bootstrap analysis P
Age (years) 1.09 (1.05–1.12) < 0.01 1.04 (1.003–1.08) 0.04 1.04 (1.01–1.08) 0.01
Female 0.62 (0.31–1.21) 0.16
Albumin (g/l) 0.90 (0.85–0.95) < 0.01
Proteinuria (g/24 h) 1.14 (1.06–1.21) < 0.01 1.09 (1.01–1.18) 0.03 1.09 (1.02–1.16) < 0.01
eGFR (ml/min/1.73 m2) 0.96 (0.95–0.97) < 0.01 0.97 (0.96–0.99) < 0.01 0.97 (0.96–0.99) < 0.01
Microscopic hematuria 0.78 (0.40–1.50) 0.45
Triglyceride (mmol/l) 1.16 (0.97–1.39) 0.11     
Cholesterol (mmol/l) 1.06 (0.93 ~ 1.22) 0.39
Uric acid (μmol/l) 1.00 (0.99–1.01) 0.20
Serum PLA2R antibody (RU/l) 1.00 (0.99–1.00) 0.28
Pathological characteristics   
 Stages I and II 1.00 (0.46–2.22) 0.99
 ≥ 50% interstitial fibrosis 6.12 (2.54–14.73) < 0.01
 PLA2R staining positive 26.08 (0.00–3 × 106) 0.59
 IgG1 positive 0.99 (0.11–9.50) 0.99   
 IgG4 positive 0.40 (0.04–3.63) 0.40