Fig. 5
From: Macrophages are necessary for skin regeneration during tissue expansion
Angiogenesis is impaired in the macrophage-depleted expanded skin. a, b Sections from control or clodronate liposomes treated expanded skin stained with Lectin (red) and DAPI (blue) to label endothelial cells and nuclei, respectively, 14 days and 35 days after expander implantation. Vessels are visible in skin sections of the representative photographs. c Significantly fewer vessels are present in macrophage-depleted expanded skin compared with that in control skin at day 14 (n = 5, p < 0.05) and day 35 (n = 8, p < 0.001). d Transcutaneous oxygen pressure showed a higher oxygen pressure in control expanded skin at day 35 (n = 8, p < 0.05)