Fig. 4
From: Macrophages are necessary for skin regeneration during tissue expansion
The effect of macrophage depletion on tissue cell proliferation during the process of tissue expansion. a, b Representative photographs of PCNA-positive cells (red) in the expanded skin. PCNA positive cells mainly located at the basal layer and hair follicles. c The total number of PCNA-positive cells in PBS-lipo side was higher than that in Clo-lipo side at day 14 (n = 5, p < 0.001) and day 35 (n = 8, p < 0.001). PCNA, anti-proliferating cell nuclear antigen; PBS-lipo, PBS liposomes; Clo-lipo, clodronate liposomes. ***p ≤ 0.001