Fig. 8

Dynamic change in circulating tumor cell (CTC) counts before and after initiation of crizotinib treatment for 8 months in one ALK-positive patient. a Tumor tissues from this patient were positive for TTF-1, CEA and CK-7. b Serial lung CT scan changes are presented. Lung tumor showed gradual shrinkage after crizotinib treatment. c Serial CTC counts by NanoVelcro and CellSearch are plotted along with radiological changes. CTC counts by NanoVelcro are always higher than CellSearch before lung tumor disappearing on CT scan after crizotinib treatment for 6 months. NanoVelcro accurately reflects the disease progressions with the disappearing of tumor, while CellSearch rebounded abnormally