Fig. 1

Study treatment schema. Treatment with PBS (negative control), BCG (positive control), intravesical (IVe) ALT-803, SQ ALT-803, IVe BCG + IVe ALT-803 and IVe BCG + SQ ALT-803 commenced on week 13 after 12 week exposure to 0.05% N-butyl-N-(4-hydroxybutyl) nitrosamine in drinking water. Mice were randomly assigned into six groups and treated weekly for six consecutive weeks according to the schedule. Three mice from each group was sacrificed and necropsied 3 days after the 1st week’s treatment. Then the remaining mice were sacrificed and necropsied on week 20. CTRL Control, IVe intravesical, SQ subcutaneous