Fig. 1

PIAS3 reduces peripheral arthritis, cartilage damage, and inflammatory cell infiltration in peripheral arthritis mice with spondyloarthritis (SpA). a The mean clinical score was determined based on arthritis severity. b Joint tissues were isolated from PIAS3 vector- or Mock vector-treated mice with SpA at 10 weeks after curdlan injection and stained with hematoxylin and eosin (H&E) and Safranin O. Arthritis score is shown in the bar graphs. c Peripheral joint tissues were stained with specific antibodies (Abs) against IL-17, TNF-α, STAT3, pSTAT3 s727, pSTAT y705, and PIAS3. Pro-inflammatory cytokine-, STAT3-, and PIAS3-positive cells are shown in the bar graphs. Data are represented as the mean ± standard error of the mean (SEM) of three independent experiments (*P < 0.05)