Table 4 Difference in clinicopathological features due to pack-years
Parameters | Smoker | p value | Pack-years | p value | ||
|---|---|---|---|---|---|---|
Yes (n = 44) | No (n = 105) | High (n = 43) | Low (n = 106) | |||
Age (years old) | ||||||
 ≤ 56 | 24 (54.5%) | 51 (48.6%) | 0.509 | 24 (55.8%) | 51 (48.1%) | 0.398 |
 > 56 | 20 (45.5%) | 54 (51.4%) | 19 (44.2%) | 55 (51.9%) | ||
Tumour size (mm) | ||||||
 ≤ 27.6 | 25 (56.8%) | 50 (47.6%) | 0.309 | 25 (58.1%) | 50 (47.2%) | 0.228 |
 > 27.6 | 19 (43.2%) | 55 (52.4%) | 18 (41.9%) | 56 (52.8%) | ||
Skin infiltration | ||||||
 Negative | 40 (90.9%) | 94 (89.5%) | 0.799 | 40 (93.0%) | 94 (88.7%) | 0.428 |
 Positive | 4 (9.1%) | 11 (10.5%) | 3 (7.0%) | 12 (11.3%) | ||
Lymph node status | ||||||
 Negative | 18 (40.9%) | 33 (31.4%) | 0.269 | 18 (41.9%) | 33 (31.1%) | 0.214 |
 Positive | 26 (59.1%) | 72 (68.6%) | 25 (58.1%) | 73 (68.9%) | ||
Ki67 | ||||||
 Negative | 6 (13.6%) | 17 (16.2%) | 0.69 | 6 (14.0%) | 17 (16.0%) | 0.752 |
 Positive | 38 (86.4%) | 88 (83.8%) |  | 37 (86.0%) | 89 (84.0%) |  |
Intrinsic subtype | ||||||
 HER2-enriched | 22 (50.0%) | 40 (38.1%) | 0.181 | 22 (51.2%) | 40 (37.7%) | 0.134 |
 Triple-negative | 22 (50.0%) | 65 (61.9%) | 21 (48.8%) | 66 (62.3%) | ||
ORR | ||||||
 Non-responders | 3 (6.8%) | 8 (7.6%) | 0.866 | 3 (7.0%) | 8 (7.5%) | 0.905 |
 Responders | 41 (93.2%) | 97 (92.4%) | 40 (93.0%) | 98 (92.5%) | ||
pCR | ||||||
 Negative | 17 (38.6%) | 58 (55.2%) | 0.065 | 16 (37.2%) | 59 (55.7%) | 0.042 |
 Positive | 27 (61.4%) | 47 (44.8%) |  | 27 (62.8%) | 47 (44.3%) |  |
Recurrence | ||||||
 Negative | 40 (90.9%) | 83 (79.0%) | 0.083 | 39 (90.7%) | 84 (79.2%) | 0.096 |
 Positive | 4 (9.1%) | 22 (21.0%) | 4 (9.3%) | 22 (20.8%) | ||
TILs | ||||||
 Low | 13 (29.6%) | 45 (42.9%) | 0.075 | 12 (27.9%) | 46 (43.4%) | 0.043 |
 High | 31 (70.5%) | 60 (57.1%) | 31 (72.1%) | 60 (56.6%) | ||