MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo

Table 1 Inverse correlations between micro-RNAs and up-regulated messenger RNAs (mRNA) which induce angiogenesis as well as down-regulated mRNAs which inhibit angiogenesis

miRNA	Gene symbol	Mean fold-change miRNA	Mean fold-change mRNA	GO term	Correlation	P-value	Weighted context++ score	Weighted context++ score percentile
mRNAs inducing angiogenesis
POD 5
let-7c-5p	CXCR2	− 4.30	10.92	0045766	− 0.66	3.31 × 10⁻⁶	− 0.193	79
let-7b-5p	CXCR2	− 3.23	10.92	0045766	− 0.64	3.47 × 10⁻⁶	− 0.157	74
miR-27b-3p	CXCR2	− 2.77	10.92	0045766	− 0.6	1.50 × 10⁻⁵	− 0.157	91
miR-10b-5p	CXCR2	− 3.76	10.92	0045766	− 0.57	3.58 × 10⁻⁵	− 0.414	98
miR-27b-3p	IL1A	− 2.77	35.67	0045766	− 0.59	1.82 × 10⁻⁵	− 0.203	94
mRNAs inhibiting angiogenesis
POD 5
miR-130b-3p	EPHA2	4.51	− 3.18	0016525	− 0.61	9.76 × 10⁻⁶	− 0.069	73
miR-223-3p	EPHA2	6.76	− 3.18	0016525	− 0.6	1.46 × 10⁻⁵	− 0.134	86
miR-223-3p	SYNJ2BP	6.76	− 2.74	1903671	− 0.73	1.85 × 10⁻⁷	− 0.013	37
miR-19b-3p	SYNJ2BP	3.63	− 2.74	0016525	− 0.58	2.96 × 10⁻⁵	− 0.052	52
POD 10
miR-19b-3p	SYNJ2BP	2.06	− 2.19	0016525	− 0.58	2.96 × 10⁻⁵	− 0.052	52
miR-223-3p	SYNJ2BP	3.95	− 2.19	0016525	− 0.73	1.85 × 10⁻⁷	− 0.086	77
POD 15
miR-511-3p	FOXC1	6.52	− 6.39	0016525	− 0.56	4.33 × 10⁻⁵	− 0.038	62
miR-223-3p	SYNJ2BP	5.12	− 1.99	0016525	− 0.73	1.85 × 10⁻⁷	− 0.086	77
miR-449a-5p	SYNJ2BP	1.75	− 1.99	0016525	− 0.64	5.74 × 10⁻⁷	− 0.143	74

Weighted context++ scores and percentiles were calculated with TargetScan (release 7.1)
GO gene ontology, POD postoperative day, CXCR2 C–X–C motive chemokine receptor 2, IL1A interleukin 1 alpha, SYNJ2BP synaptojanin-2 binding protein, EPHA2 ephrin receptor 2 A, FOXC1 forkhead box C1

ISSN: 1479-5876