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Table 1 Inverse correlations between micro-RNAs and up-regulated messenger RNAs (mRNA) which induce angiogenesis as well as down-regulated mRNAs which inhibit angiogenesis

From: MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo

miRNA Gene symbol Mean fold-change miRNA Mean fold-change mRNA GO term Correlation P-value Weighted context++ score Weighted context++ score percentile
mRNAs inducing angiogenesis
 POD 5
  let-7c-5p CXCR2 − 4.30 10.92 0045766 − 0.66 3.31 × 10−6 − 0.193 79
  let-7b-5p CXCR2 − 3.23 10.92 0045766 − 0.64 3.47 × 10−6 − 0.157 74
  miR-27b-3p CXCR2 − 2.77 10.92 0045766 − 0.6 1.50 × 10−5 − 0.157 91
  miR-10b-5p CXCR2 − 3.76 10.92 0045766 − 0.57 3.58 × 10−5 − 0.414 98
  miR-27b-3p IL1A − 2.77 35.67 0045766 − 0.59 1.82 × 10−5 − 0.203 94
mRNAs inhibiting angiogenesis
 POD 5
  miR-130b-3p EPHA2 4.51 − 3.18 0016525 − 0.61 9.76 × 10−6 − 0.069 73
  miR-223-3p EPHA2 6.76 − 3.18 0016525 − 0.6 1.46 × 10−5 − 0.134 86
  miR-223-3p SYNJ2BP 6.76 − 2.74 1903671 − 0.73 1.85 × 10−7 − 0.013 37
  miR-19b-3p SYNJ2BP 3.63 − 2.74 0016525 − 0.58 2.96 × 10−5 − 0.052 52
 POD 10
  miR-19b-3p SYNJ2BP 2.06 − 2.19 0016525 − 0.58 2.96 × 10−5 − 0.052 52
  miR-223-3p SYNJ2BP 3.95 − 2.19 0016525 − 0.73 1.85 × 10−7 − 0.086 77
 POD 15
  miR-511-3p FOXC1 6.52 − 6.39 0016525 − 0.56 4.33 × 10−5 − 0.038 62
  miR-223-3p SYNJ2BP 5.12 − 1.99 0016525 − 0.73 1.85 × 10−7 − 0.086 77
  miR-449a-5p SYNJ2BP 1.75 − 1.99 0016525 − 0.64 5.74 × 10−7 − 0.143 74
  1. Weighted context++ scores and percentiles were calculated with TargetScan (release 7.1)
  2. GO gene ontology, POD postoperative day, CXCR2 C–X–C motive chemokine receptor 2, IL1A interleukin 1 alpha, SYNJ2BP synaptojanin-2 binding protein, EPHA2 ephrin receptor 2 A, FOXC1 forkhead box C1