Fig. 5
From: MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo
Histologic analysis of arteriovenous shunts. Histologic analysis of hematoxylin/eosin stained cross sections of explanted vascular constructs on postoperative day (POD) 5 (a, b), 10 (b, c), and 15 (d, e) show ink-perfused vessel lumina of both saphenous artery (*) and vein (#). Early intramural vessel sprouting was detected within the wall of the saphenous artery (*) on POD 5 (b, black arrow). Neoangiogenesis within the acellular dermal matrix (ADS) surrounding the saphenous vein (#) was clearly visible on POD 10 (blue arrowheads, d). Neoangiogenesis had strongly expanded and surrounded both artery (*) and vein (#) on POD 15 (e, f, blue arrowheads). An accumulation of erythrocytes (E) around the main vessels was seen on POD 10 (c and d)