Table 1 Analysis of differentially expressed genes and pathways
From: IL-23 and PSMA-targeted duo-CAR T cells in Prostate Cancer Eradication in a preclinical model
Top enhanced Gene Ontogeny pathway | Gene count | |
|---|---|---|
1 | Mitotic cell cycle process | 52 |
2 | Cell cycle | 59 |
3 | Mitotic nuclear division | 39 |
4 | Cell division | 22 |
5 | Regulation of cell cycle | 42 |
6 | DNA replication | 21 |
7 | Small GTPase mediated signal transduction | 29 |
8 | Intracellular signal transduction | 22 |
9 | Positive regulation of mitotic cell cycle | 13 |
10 | Cytokinesis | 10 |
11 | Response to cytokine | 12 |
Top upregulated gene symbol | Fold change | |
|---|---|---|
1 | IL13 | 10.1 |
2 | IL4 | 5.9 |
3 | IL5 | 3.5 |
4 | IL4 | 3.1 |
5 | EPAS1 | 2.9 |
6 | IFNG | 1.7 |
7 | CSF2 | 1.5 |
8 | PTGS2 | 1.5 |
9 | ARG2 | 1.5 |
10 | CCL3 | 1.5 |
Top enhanced KEGG pathway description | Gene count | |
|---|---|---|
1 | Cytokine‐cytokine receptor interaction | 14 |
2 | TNF signalling pathway | 8 |
3 | T cell receptor signalling pathway | 5 |
4 | Jak-STAT signalling pathway | 7 |
5 | Trancriptional misregulation | 4 |
6 | p53 signalling pathway | 6 |
7 | Cell cycle | 7 |
8 | Toll‐like receptor signaling pathway | 7 |
9 | Adipocytokine signaling pathway | 5 |
10 | Fc epsilon RI signaling pathway | 5 |