Parameter | AUC (95% CI) | Cut-off | Accuracya | Sensitivity | Specificity | PPV | NPV | Fold differenceb |
|---|
CSF cell count | 0.93c (0.89–0.97) | > 1000 cells/μL | 70.0 | 40.6 | 99.4 | 92.9 | 89 | 64.7 |
PC ae C44:6 | 0.93c (0.87–0.99) | > 5 nM | 90.5 | 90.6 | 90.3 | 65.9 | 97.9 | 6.8 |
- Values were obtained by ROC analysis. Sensitivity, specificity, positive and negative predictive value (PPV and NPV) were determined at the trade-off value (Youden index), corresponding to the maximal value of (sensitivity + specificity)/2 in the case of PCaeC44:6 and the clinically recommended cut-off for cell count. Diagnostic groups included in the analysis: bacterial meningitis (n = 32), HSV encephalitis (n = 9), varicella zoster virus meningoencephalitis (n = 15), enterovirus meningitis (n = 10), facial zoster (n = 16), segmental zoster (n = 14), anti-NMDA-receptor autoimmune encephalitis (n = 8), multiple sclerosis (n = 17), Tourette syndrome (n = 20), Bell’s palsy (n = 11), and normal pressure hydrocephalus (n = 35)
- AUC area under the curve, CI confidence interval, ROC receiver operating characteristic
- aDefined as (sensitivity + specificity)/2 at the cut-off value, bratio of mean values, bacterial meningitis/all others, casymptotic significance, P < 0.001
