Fig. 3

Differentially expressed genes in TCs with LPS treatment. a Heat map of differential expressed miRNAs in cultured TCs stimulated with LPS. b Heat map of differential expressed genes in cultured TCs stimulated with LPS. c Relationship between differential expressed miRNAs and their differential expressed target mRNAs. Yellow indicated miRNAs, green indicated downregulated mRNAs, and red indicated upregulated mRNAs. d Interaction of the angiogenesis-related proteins in STRING. Different colours indicated the involvement of proteins in different processes. Red indicated angiogenesis, pink indicated blood vessel morphogenesis, purple indicated vasculature development, brown indicated blood vessel remodelling, blue indicated sprouting angiogenesis, cyan indicated venous blood vessel sprouting, orange indicated venous blood vessel morphogenesis, green indicated regulation of angiogenesis, and yellow indicated positive regulation of angiogenesis. e Angiogenesis related miRNAs and their downstream genes. Red indicated upregulated miRNAs, green indicated downregulated miRNAs, yellow indicated genes that were enriched in more than three processes in STRING, blue indicated other mRNAs