Table 2 GRADE profile of ITF supplementation for FBG, HbA1c, and FINS levels and HOMA-IR scores in the total population and in the prediabetes and T2DM population
Quality assessment | Summary of findings | Quality of evidence | |||||||
|---|---|---|---|---|---|---|---|---|---|
Outcomes | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication Bias | Number of intervention/control | Absolute effect (95% CI) | Relative effecta intervention/control | |
FBG (Total population) | No serious limitations | Serious limitationsb | No serious limitations | No serious limitations | No serious limitations | 656/651 | − 0.21 (− 0.33, − 0.09) mmol/l | − 4.32%/0.36% | ⊕ ⊕ ⊕○ moderate |
HbA1C (Total population) | No serious limitations | Serious limitationsc | No serious limitations | No serious limitations | No serious limitations | 220/219 | − 0.39 (− 0.65, − 0.13) % | − 4.93%/1.20% | ⊕ ⊕ ⊕○ moderate |
FINS (Total population) | No serious limitations | Very serious limitationsd | No serious limitations | No serious limitations | Strongly suspectede | 515/514 | − 1.22 (− 1.90, − 0.54) μU/ml | − 12.62%/0.44% | ⊕ ○○○ very low |
HOMA-IR (Total population) | No serious limitations | Very serious imitationsf | No serious limitations | No serious limitations | No serious limitations | 357/360 | − 0.57 (− 0.84, − 0.31) | − 19.10%/− 1.27% | ⊕ ⊕ ○○ low |
FBG (T2DM and prediabetes) | No serious limitations | No serious limitations | No serious limitations | No serious limitations | No serious limitations | 283/280 | − 0.60 (− 0.71, − 0.48) mmol/l | − 7.41%/− 0.26% | ⊕ ⊕ ⊕ ⊕ high |
HbA1C (T2DM and prediabetes) | No serious limitations | No serious limitations | No serious limitations | No serious limitations | No serious limitations | 190/189 | − 0.58 (− 0.83, − 0.32) % | − 5.15%/1.55% | ⊕ ⊕ ⊕ ⊕ high |
FINS (T2DM and prediabetes) | No serious limitations | Very serious limitationsg | No serious limitations | No serious limitations | No serious limitations | 232/229 | − 1.75 (-2.87, − 0.63) μU/ml | − 20.08%/− 3.50% | ⊕ ⊕ ○○ low |
HOMA-IR (T2DM and prediabetes) | No serious limitations | Very serious limitationsh | No serious limitations | No serious limitations | No serious limitations | 195/197 | − 0.69 (− 1.10, − 0.28) | − 27.63%/− 2.29% | ⊕ ⊕ ○○ low |