Table 3 Multivariate linear regression on the effects of being a case on GDF15 concentrations
From: Circulating levels of GDF15 in patients with myalgic encephalomyelitis/chronic fatigue syndrome
Variable | Coefficienta (pg/ml) | 95% confidence interval | p-valueb |
|---|---|---|---|
Case status | 0.08 | ||
Healthy control | – | ||
MS | 34.3 | − 33.7 to 102.4 | 0.3 |
ME/CFS mild/moderate | 48.3 | − 9.0 to 105.6 | 0.1 |
ME/CFS severe | 91.2 | 19.6 to 162.7 | 0.01 |
Sex (female) | − 28.5 | − 73.7 to 16.8 | 0.2 |
Agec (years) | 3.9 | 1.8 to 6.1 | < 0.0001 |
Body mass index (Kg/m2)c | 3.3 | − 1.4 to 8.0 | 0.2 |
Activity level | 0.05 | ||
Little activity | – | ||
Average activity | 66.7 | 7.2 to 126.3 | 0.03 |
Active | 45.2 | − 8.7 to 99.1 | 0.1 |
Smoking status | 0.04 | ||
Never smoked | – | ||
Previous smoker | 7.7 | − 38.0 to 53.3 | 0.7 |
Current smoker | 92.6 | 19.2 to 165.9 | 0.01 |
CRP (mg/L) | 6.9 | 2.5 to 11.2 | 0.002 |
eGFR(ml/min/1.73 m2) | − 4.0 | − 6.3 to − 1.6 | 0.001 |