Table 2 Summary of primary outcomes from selected studies
From: Ovarian function and reproductive outcome after ovarian tissue transplantation: a systematic review
Total number of patients in study | Second transplantation | Third transplantation | Transplantation site | Number of patient with therapeutic outcome | Onset of ovarian function | Duration of Ovarian function | FSH below 20 (IU/l) | E2 above 100 (pg/ml) | Follicular growth | (Author, year) |
|---|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | Right pelvic side wall in peritoneal pocket | 1 | 2.5Â months | Not reported | 1 | 1 | 1 | Dittrich et al. 2008 [15] |
1 | 0 | 0 | Pouch of peritoneum in the Board ligament | 1 | 3Â months | Not reported | 1 | 1 | 1 | Dittrich et al. 2012 [16] |
20 | 0 | 0 | Peritoneal pocket, below the fallopian tube, Pelvic wall, Ovary | 19 | 4Â months | average 1.7Â years and Ongoing in 13 patient to date of study | ND | 19 | ND | Dittrich et al. 2015 [17] |
1 | 0 | 0 | Ovarian fossa of the right pelvic wall | 1 | 3Â months | Not reported | 1 | 1 | 1 | Muller et al. 2012 [18] |
1 | 0 | 0 | Right forearm | 1 | Not reported | 7 months | ND | 1 | 1 | Wølner-Hanssen et al. 2005 [19] |
1 | 0 | 0 | Ovary | 1 | 4Â months | 5Â months ongoing | 1 | ND | 1 | Burmeister et al. 2013 [20] |
1 | 0 | 0 | Ovary | 1 | 3Â months | 12Â months | 1 | ND | 1 | Revelli et al. 2013 [21] |
1 | 0 | 0 | Ovary | 1 | 6Â months | 2Â years ongoing | ND | ND | 1 | Kiseleva et al. 2015 [22] |
1 | 0 | 0 | Residual left ovary, right peritoneal bursa and trocar incision | 1 | 4Â months | 4Â years | 1 | 1 | 1 | Demeestere et al. 2015 [10] |
1 | 0 | 0 | Ovary | 1 | Not reported | 4Â years ongoing | ND | ND | 1 | Ernst et al. 2010 [23] |
1 | 0 | 0 | Lower abdominal wall | 1 | 2Â months | 5Â years | 1 | ND | 1 | Oktay et al. 2011 [24] |
47 | 0 | 0 | Orthotopic site | 1 | 3Â months | Not reported | ND | ND | ND | Biasin et al. 2015 [25] |
14 | 0 | 0 | Arm (SC), rectus abdominis muscle | 3 | 2–4 months | Not reported | 3 | 3 | 3 | Callejo et al. 2001 [26] |
3 | 0 | 0 | Ovarian cortex | 3 | 3.5–7 months | 1 years | 3 | 3 | 3 | Donnez et al. 2010 [27] |
3 | 0 | 0 | Subcutaneous pockets | 3 | 2–4 months | 91, 61 and 76 weeks ongoing | 3 | 3 | 3 | Fabbri et al. 2014 [28] |
10 | 2 | 0 | Peritoneal incision close to the ovary or on decorticated ovaries | 9 | 3.5–7 months | 9–86 months 17–28 months | 6 | 5 | ND | Janse et al. 2011 [29] |
41 | 11 | 1 | Remaining ovary and into a peritoneal pocket | 40 | Not reported | Not reported | 40 | ND | ND | Jensen et al. 2015 [30] |
5 | 4 | 0 | Heterotopic site such as rectus muscle and sheath | 5 | 2–4 months | 9–84 months | 1 | 1 | 1 | Kim et al. 2012 [31] |
56 | 0 | 0 | Ovary | 1 | Not reported | 30Â months | ND | ND | 1 | Meirow et al. 2007 [32] |
1 | 1 | 0 | Peritoneal pocket, left ovary | ND | Not reported | Not reported | ND | ND | 1 | Fabbri et al. 2018 [33] |
20 | 0 | 0 | Subcortical tunnels and peritoneum in the ovarian ligaments | 19 | Not reported | Not reported | 12 | 11 | ND | Meirow et al. 2016 [34] |
25 | 0 | 0 | Denuded medulla | 22 | 4.5 months | All more than 2 years, ½ 6 years, 2 for 8 years | 22 | ND | ND | Silber et al. 2010 [35] |
47 | 0 | 0 | Beneath the serosa of fallopian tubes | ND | Not reported | Not reported | ND | ND | 9 | Suzuki et al. 2015 [36] |
164 | 0 | 0 | Remaining ovary | 2 | Not reported | 40Â months | ND | ND | ND | Tanbo et al. 2015 [37] |
399 | 5 | 1 | Peritoneal pocket | 19 | 1Â years | Not reported | ND | ND | ND | Beckmann et al. 2017 [38] |
1 | 0 | 0 | Three fragments were placed into the incision in the ovary and nine into the peritoneal pocket | 1 | 3Â months | Not reported | 1 | 1 | 1 | Demeestere et al. 2006 [39] |
225 | 1 | 0 | Peritoneal and ovarian sites and orthotopic site. Other peritoneal sites including ovarian bursa and subcutaneous abdominal trocar incision | 4 | 2–5 months | 1–5 years 3 cases ongoing | 4 | N | N | Imbert et al. 2014 [40] |
1 | 0 | 0 | Ovarian fossa and broad ligament | 1 | Not reported | Not reported | 1 | 1 | 1 | Povoa et al. 2016 [41] |
22 | 2 | 2 | Peritoneum of the denuded fallopian tube isthmus | 11 | 60–130 days | 3–4 years | 11 | ND | ND | Silber et al. 2015 [11] |