Fig. 3

Differential analyses of gene methylation and expression status between invasive and non-invasive tumors. a The volcano plot shows 8842 differentially methylated probes (invasive vs non-invasive tumor), indicating 2780 hypomethylated probes (blue) and 6062 hypermethylated probes (red). b The heatmap shows the methylation profiles of 68 NFPA samples. The rows represent the different probes and the columns represent each sample. The color in the heatmap represents the methylation level difference, which are hypermethylation (yellow) and hypomethylation (blue). The bar on the top shows the clinical and grouping information, and the patient ID is on the bottom. c The volcano plot shows 661 differentially expressed genes, with 206 upregulated genes (red) and 455 downregulated genes (blue). d The heatmap shows the expression profiles of the 68 NFPA samples. The rows represent the different genes and the columns represent each sample. The color in the heatmap represents the expression level difference: upregulated (red) and downregulated (green). The bar on the top shows the clinical and grouping information, and the patient ID is on the bottom