Downregulation of exosomal miR-192-5p and miR-204-5p in subjects with nonclassic apparent mineralocorticoid excess

Table 4 Target genes of miR-204-5p and 192-5p and its predicted renal and global effect

miRNA (downregulated in NC-AME)	Target gene	Affected pathway	Predicted renal effect	Global effect	References
miR-204-5p	NR3C2 NEDD4-2 YWHAG (14-3-3 protein gamma) ATP1A4 ATP1B1 DNMT3a	ENaC channel activity; NCC symporter activity. Na⁺/K⁺ exchange DNA Methylation	Increased renal Na⁺ reabsorption Increased promoter methylation of HSD11B2 gene	Increase plasma volume (low renin); High BP. Decreased cortisol to cortisone metabolism; High F/E ratio	[33] [34, 40,41,42] [36,37,38]
miR-192-5p	ATP1A1 ATP1A2 RAC1 ARHGAP ARHGEF	Na⁺/K⁺ exchange Sodium reabsorption independent of aldosterone	Increased renal Na⁺ reabsorption	Increase plasma volume (low renin); high BP	[25] [26] [28,29,30,31]

ISSN: 1479-5876