miRNA (downregulated in NC-AME) | Target gene | Affected pathway | Predicted renal effect | Global effect | References |
---|---|---|---|---|---|
miR-204-5p | NR3C2 NEDD4-2 YWHAG (14-3-3 protein gamma) ATP1A4 ATP1B1 DNMT3a | ENaC channel activity; NCC symporter activity. Na+/K+ exchange DNA Methylation | Increased renal Na+ reabsorption Increased promoter methylation of HSD11B2 gene | Increase plasma volume (low renin); High BP. Decreased cortisol to cortisone metabolism; High F/E ratio | [33] |
miR-192-5p | ATP1A1 ATP1A2 RAC1 ARHGAP ARHGEF | Na+/K+ exchange Sodium reabsorption independent of aldosterone | Increased renal Na+ reabsorption | Increase plasma volume (low renin); high BP | [25] [26] |