Fig. 3

The expression of AGXT, ALDOB, CYP2E1, IGFBP3 and TOP2A predicted clinical outcome in HCC. The prognostic value of the 37 high frequent genes was evaluated by survival risk prediction in a cohort of 247 Chinese HCC patients (Gene Expression Omnibus Accession number GSE14520). BRB-Array Tools (version 4.3.1) was used for survival risk prediction. Among the 37 genes, under-expression of three genes (alanine-glyoxylate and serine-pyruvate aminotransferase, AGXT; aldolase B, ALDOB; cytochrome P450 family 2 subfamily E member 1, CYP2E1) and over-expression of two genes (insulin-like growth factor binding protein-3, IGFBP3; topoisomerase 2α, TOP2A) were significantly correlated to poor prognosis. Red line represented samples with over-expressed gene, and blue line represented samples with under-expressed gene