Fig. 1

The inhibition of endothelial cells proliferation induced by OxLDL is mediated by TSP-1. OxLDL incubation induced an increase of ADAMTS-1 expression in HAEC without effect on TSP-1 and PhosphoVEGF-R2 protein expression (a; N = 3). Alpha5beta3 integrin expression on HAEC was reduced by OxLDL and human recombinant TSP-1 (b; N = 3). OxLDL enriched culture medium induced an increases secretion of TSP-1 by HAEC (c, N = 3). The inhibition of VEGF-proliferation cells induced by OxLDL was limited by SiRNA targeted TSP-1 (D, N = 4)