Fig. 4

Comparison of 0 → 5 and 5 → 10 DNA methylation changes. a Venn diagrams illustrating the overlap between 0 → 5 and 5 → 10 dmCpGs (the results of a Fisher’s test for over-enrichment of the overlap is shown). b Plots illustrating the age-dependent change in β-value for 4 examples of dmCpGs common to both 0 → 5 and 5 → 10 (see Additional file 12: Figure S4 for all 36 CpG plots). c Network of gene–enhancer interactions observed between dmCpGs mapped to enhancer elements in blood tissue and cell types and associated genes. The number of connections between nodes reflects the mapping of a dmCpG to enhancers in more than one track