Table 1 Summary of OS data
From: Immunotherapy Bridge 2018 and Melanoma Bridge 2018: meeting abstracts
| Â | Median OS, months (95% CI) | HR (95% CI) | |
|---|---|---|---|
IPI 10Â mg/kg | IPI 3Â mg/kg | IPI 10Â mg/kg vs IPI 3Â mg/kg | |
ITT population | 15.7 (11.6, 17.8) | 11.5 (9.9, 13.3) | 0.84 (0.71, 0.99) |
BRAF mutant | 33.2 (19.4, 45.2) | 19.7 (11.6, 25.3) | 0.70 (0.48, 1.02) |
BRAF wild-type | 13.8 (10.2, 17.0) | 11.2 (9.2, 13.8) | 0.90 (0.73, 1.11) |
M0/M1a/M1b | 25.9 (22.2, 36.3) | 18.7 (15.3, 23.0) | 0.77 (0.58, 1.02) |
M1c no brain metastases | 10.8 (8.2, 16.0) | 10.9 (8.3, 13.1) | 0.92 (0.71, 1.17) |
M1c with brain metastases | 7.0 (4.0, 12.8) | 5.7 (4.2, 7.0) | 0.72 (0.50, 1.05) |