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Table 1 Clinical and laboratory characteristics of all the patients

From: Application of expanded genetic analysis in the diagnosis of familial hypercholesterolemia in patients with very early-onset coronary artery disease

Characteristics Total (n = 105)
Age, years 31.69 ± 5.65
Male, n (%) 99 (94.3)
BMI, kg/(m2) 29.07 ± 20.14
Family history of premature CAD, n (%) 20 (19.0)
History of MI, n (%) 52 (49.5)
Currently smoking, n (%) 70 (66.7)
Alcohol drinker, n (%) 42 (40.0)
Hypertension, n (%) 46 (43.8)
DM, n (%) 17 (16.2)
Statin, n (%) 81 (77.1)
TG, mmol/L 1.80 ± 0.84
TC, mmol/L 6.62 ± 7.49
HDL-C, mmol/L 0.89 ± 0.26
LDL-C, mmol/L 5.77 ± 3.38
Lp(a), mg/dL 210.40 (65.75–496.06)
Xanthoma, n (%) 12 (11.4)
Mutations, n (%) 40 (38.1)
 LDLR, n (%) 15 (14.3)
 APOB, n (%) 7 (6.7)
 PCSK9, n (%) 2 (1.9)
 STAP1, n (%) 1 (1.0)
 LDLR Homozygote, n (%) 4 (4.8)
 Two mutations, n (%) 11 (10.5)
  1. Data are expressed as mean ± SD, or n (%). BMI body mass index, CAD coronary artery disease, MI myocardial infarction, DM diabetes mellitus, TG triglyceride, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, Lp(a) lipoprotein (a), APOB apolipoprotein B, LDLR low-density lipoprotein receptor, PCSK9 proprotein convertase subtilisin/Kexin type 9, STAP1 signal-transducing adaptor protein 1
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