A specific protocol of autologous bone marrow concentrate and platelet products versus exercise therapy for symptomatic knee osteoarthritis: a randomized controlled trial with 2 year follow-up

Table 4 Clinical outcome baseline and change score averages at each post-treatment visit (treatment and crossover data combined)

Metric	Visit	N	Mean/change score*	SD	p-value	Metric	Visit	N	Mean/change score*	SD	p-value
VAS (mm)	Baseline	48	39	21		LEAS	Baseline	48	12	3
	6-week	48	− 17	18	< 0.001		6-week	48	0.3	2	0.903
	3-month	46	− 14	16	< 0.001		3-month	46	0.8	2	0.081
	6-month	45	− 19	17	< 0.001		6-month	45	1.1	3	0.007
	1-year	43	− 15	20	< 0.001		1-year	43	1.1	2	0.004
	2-year	42	− 14	24	< 0.001		2-year	42	1.2	3	0.004
KSS-knee score	Baseline	48	76	9		KSS-function score	Baseline	48	84	13
	6-week	47	11	9	< 0.001		6-week	48	7	13	< 0.001
	3-month	44	13	11	< 0.001		3-month	46	9	12	< 0.001
	6-month	45	14	8	< 0.001		6-month	45	9	13	< 0.001
	1-year	43	11	12	< 0.001		1-year	43	7	13	< 0.001
	2-year	42	13	11	< 0.001		2-year	42	8	12	< 0.001
SF-12 physical	Baseline	48	39	9		SF-12 mental	Baseline	48	58	6
	6-week	48	5	9	< 0.001		6-week	48	1.0	7	0.918
	3-month	46	7	9	< 0.001		3-month	46	1.4	6	0.714
	6-month	45	8	11	< 0.001		6-month	45	1.8	9	0.340
	1-year	43	7	10	< 0.001		1-year	43	2.2	9	0.138
	2-year	41	9	11	< 0.001		2-year	41	2.6	10	0.055
ROM (degrees)	Baseline	48	131	9
	6-week	47	1.5	6	0.713
	3-month	44	3.0	6	0.052
	6-month	45	4.0	6	0.001
	1-year	43	2.5	9	0.205
	2-year	42	1.2	8	0.895

p-value compared to baseline scores
* Values for baseline are means and for all follow-up time points are change score means

ISSN: 1479-5876