Table 1 GCX flow and/or chemical treatment with rationale, where applicable

Flow stimulus

 Static

Yes

Yes

To assess whether GCX controls baseline EC behavior (as opposed to flow-induced EC behavior)

 Uniform

Yes

Yes

To assess whether EC behavior in UF only occurs due to endothelium coverage by the GCX

 Disturbed

Yes

Rationale

To assess GCX expression and EC behavior in response to both pro- and anti-atherosclerotic flow patterns