Skip to main content

Advertisement

Table 3 Associations of circadian pathway genes with predisposition to sarcoma under 3 models of inheritance: additive, recessive, dominant

From: Associations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis

Gene SNP ID Minor allele Additive Recessive Dominant
OR [95% CI] P-val. OR [95% CI] P-val. OR [95% CI] P-val.
CLOCK rs1801260 C 0.74 [0.55–1.00] 0.05 0.40 [0.18–0.88] 0.02 0.79 [0.541.14] 0.20
  rs3736544 A 1.15 [0.891.50] 0.29 1.10 [0.661.83] 0.72 1.27 [0.871.86] 0.22
  rs3749474 T 1.06 [0.811.38] 0.68 0.94 [0.541.62] 0.82 1.15 [0.791.67] 0.47
NPAS2 rs895520 A 1.33 [1.02–1.73] 0.03 1.70 [1.08–2.68] 0.02 1.30 [0.871.93] 0.20
  rs2305160 A 0.95 [0.721.26] 0.71 0.97 [0.521.79] 0.92 0.92 [0.641.34] 0.68
PER1 rs3027178 G 0.80 [0.611.06] 0.12 0.72 [0.391.35] 0.31 0.76 [0.531.10] 0.15
PER2 rs934945 T 0.65 [0.45–0.94] 0.02 0.48 [0.102.25] 0.35 0.63 [0.42–0.95] 0.03
  rs7602358 G 1.21 [0.901.62] 0.21 1.18 [0.562.48] 0.66 1.29 [0.891.86] 0.18
RORA rs339972 C 0.71 [0.53–0.96] 0.02 0.69 [0.351.36] 0.28 0.64 [0.44–0.93] 0.02
  rs10519097 T 0.98 [0.681.40] 0.89 0.55 [0.122.53] 0.44 1.02 [0.691.51] 0.93
TIMELESS rs774027 T 0.98 [0.761.26] 0.85 1.02 [0.671.55] 0.92 0.92 [0.611.39] 0.69
  rs3809125 T 0.92 [0.701.20] 0.52 0.89 [0.511.55] 0.67 0.89 [0.621.30] 0.55
  rs7302060 C 0.98 [0.761.27] 0.89 1.03 [0.651.62] 0.91 0.94 [0.631.39] 0.75
  1. Italic values indicate statistically significant associations (P < 0.05)
  2. OR [95% CI] Odds Ratio [95% Confidence Interval], P-val. P-value