Scrub typhus and depression: a nationwide cohort analysis

Table 2 Incidence and Hazard ratio for depression and depression-associated risk factor

Variable	Event	Person-years	Rate^a	Crude HR (95% CI)	Adjusted HR^b (95% CI)
Scrub typhus
No	117	108,433	1.08	1.00	1.00
Yes	45	26,905	1.67	1.55 (1.41, 1.70)*	1.56 (1.42, 1.71)*
Sex
Female	72	46,692	1.54	1.52 (1.39, 1.65)*	1.35 (1.24, 1.47)*
Male	90	88,645	1.02	1.00	1.00
Age, year
≤ 49	77	81,148	0.95	1.00	1.00
50–64	50	35,400	1.41	1.49 (1.35, 1.64)*	1.10 (0.99, 1.22)
65 +	35	18,789	1.86	1.96 (1.76, 2.19)*	1.26 (1.11, 1.42)*
Diabetes
No	133	124,334	1.07	1.00	1.00
Yes	29	11,003	2.64	2.46 (2.21, 2.75)*	1.53 (1.35, 1.73)*
Hypertension
No	125	120,702	1.04	1.00	1.00
Yes	37	14,636	2.53	2.44 (2.21, 2.70)*	1.41 (1.24, 1.59)*
Hyperlipidemia
No	141	129,514	1.09	1.00	1.00
Yes	21	5823	3.61	3.31 (2.92, 3.76)*	2.08 (1.81,2 .40)*
CAD
No	144	130,203	1.11	1.00	1.00
Yes	18	5133	3.51	3.17 (2.77, 3.63)*	1.51 (1.29, 1.76)*
Stroke
No	150	131,863	1.14	1.00	1.00
Yes	12	3474	3.45	3.04 (2.58, 3.57)*	1.52 (1.27, 1.81)*

^aIncidence rate, per 1000 person-years; Crude HR, relative hazard ratio
^bMultivariable analysis including age, sex, and comorbidities of diabetes, hypertension, hyperlipidemia, CAD and stroke
* P < 0.05

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