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Table 2 Correlations between clinicopathological features and the number of TILs

From: Possibility of avoiding axillary lymph node dissection by immune microenvironment monitoring in preoperative chemotherapy for breast cancer

Parameters

TILs

p value

High (n = 12)

Low (n = 4)

Age

 ≤ 47

7 (58.3%)

1 (25.0%)

 

 > 47

5 (41.7%)

3 (75.0%)

0.278

Tumor size

 ≤ 25

6 (50.0%)

2 (50.0%)

 

 > 25

6 (50.0%)

2 (50.0%)

1.000

Estrogen receptor

 Negative

7 (58.3%)

0 (0.0%)

 

 Positive

5 (41.7%)

4 (100.0%)

0.044

Progesterone receptor

 Negative

9 (75.0%)

1 (25.0%)

 

 Positive

3 (25.0%)

3 (75.0%)

0.082

HER2

 Negative

4 (33.3%)

4 (100.0%)

 

 Positive

8 (66.7%)

0 (0.0%)

0.019

Ki67

 Negative

2 (16.7%)

2 (50.0%)

 

 Positive

10 (83.3%)

2 (50.0%)

0.207

Intrinsic subtype HRBC

 Non-HRBC

7 (58.3%)

0 (0.0%)

 

 HRBC

5 (41.7%)

4 (100.0%)

0.044

Intrinsic subtype HER2BC

 Non-HER2BC

8 (66.7%)

4 (100.0%)

 

 HER2BC

4 (33.3%)

0 (0.0%)

0.207

Intrinsic subtype TNBC

 Non-TNBC

9 (75.0%)

4 (100.0%)

 

 TNBC

3 (25.0%)

0 (0.0%)

0.298

Number of sentinel lymph nodes with metastasis

 1, 2

10 (83.3%)

3 (75.0%)

 

 3

2 (16.7%)

1 (25.0%)

0.734

Size of sentinel lymph node itself (mm)

 ≤ 12.5

6 (50.0%)

2 (50.0%)

 

 > 12.5

6 (50.0%)

2 (50.0%)

1.000

Size of metastatic lesion

 ≤ 3400

5 (41.7%)

3 (75.0%)

 

 > 3400

7 (58.3%)

1 (25.0%)

0.278

Clinical response

 cPR

10 (83.3%)

4 (100.0%)

 

 cCR

2 (16.7%)

0 (0.0%)

0.417

Pathological complete response

 Non-pCR

7 (58.3%)

4 (100.0%)

 

 pCR

5 (41.7%)

0 (0.0%)

0.136

  1. TILs tumor-infiltrating lymphocytes, HER2 human epidermal growth factor receptor 2, HRBC hormone receptor-positive breast cancer, HER2BC HER2-enriched breast cancer, TNBC triple negative breast cancer, cPR clinical partial response, cCR clinical complete response, pCR pathological complete response