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Table 3 Associations between PD-L1, pSTAT3 and other clinicopathologic factors in diffuse large B cell lymphoma (n = 107)

From: Clinicopathologic implication of PD-L1 and phosphorylated STAT3 expression in diffuse large B cell lymphoma

 

PD-L1i

PD-L1 translocation (A)

PD-L1 gain/amplification (B)

PD-L1 gene alteration (A + B)

PD-L1 non-genetic expressionb

pSTAT3a (continuous)

pSTAT3 (> 40%)

PD-L1t

R = 0.325

p = 0.001

R = 0.477

p < 0.001

R = 0.386

p < 0.001

R = 0.629

p < 0.001

R = 0.698

p < 0.001

R = 0.079

p = 0.429

R = 0.071

p = 0.466

PD-L1i

 

R = 0.239

p = 0.015

R = 0.159

p = 0.109

R = 0.291

p = 0.003

R = 0.166

p = 0.092

R = 0.081

p = 0.414

R = 0.015

p = 0.879

PD-L1 translocation (A)

  

R = − 0.051

p = 0.614

R = 0.758

p < 0.001

R = − 0.090

p = 0.364

R = − 0.049

p = 0.628

R = − 0.037

p = 0.714

PD-L1 gain/amplification (B)

   

R = 0.613

p < 0.001

R = − 0.073

p = 0.464

R = − 0.117

p = 0.242

R = − 0.072

p = 0.470

PD-L1 gene alteration (A + B)

    

R = − 0.120

p = 0.228

R = − 0.117

p = 0.245

R = − 0.021

p = 0.835

PD-L1 non-genetic expressionb

     

R = 0.205

p = 0.033

R = 0.120

p = 0.224

  1. Correlation coefficients (R) and p values by Pearson’s correlation
  2. a Indicates the proportion (%) of tumor cells expressing pSTAT3 by using digital image analyzer
  3. b Indicates PD-L1t+ cases with no alteration (translocation or gain/amplification) of PD-L1 gene