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Table 4 Univariate and multivariate analyses with respect to post-recurrence survival in breast cancer subtypes

From: Significance of intrinsic breast cancer subtypes on the long-term prognosis after neoadjuvant chemotherapy

  Univariate analysis Multivariate analysis
Hazard ratio 95% CI p-value Hazard ratio 95% CI p-value
All breast cancer (n = 55)
 Age (≤ 56) 0.639 0.301–1.331 0.231 0.369 0.076–1.337 0.135
 Menopause (−) 0.651 0.289–1.380 0.268 1.936 0.518–9.476 0.340
 Tumor size (> 2) 2.262 0.666–14.138 0.216 5.534 1.251–39.387 0.023
 Lymph node (+) 0.760 0.288–2.611 0.627 0.295 0.083–1.207 0.086
 Nuclear grade (3) 1.308 0.516–2.921 0.547 0.751 0.256–2.016 0.577
 Ki67 (> 14) 1.797 0.859–3.881 0.120 2.606 1.028–6.780 0.044
 Pathological response (non-pCR) 3.321 1.264–11.437 0.013 4.355 1.438–16.871 0.008
 Metastasis site (distant) 1.415 0.666–2.950 0.359 2.496 1.007–6.126 0.048
 Relapse-free survival (< 2 years) 2.439 1.005–7.269 0.049 1.938 0.681–6.598 0.225
Luminal (n = 23)
 Age (≤ 56) 1.228 0.382–3.948 0.724 5.415 0.194–115.713 0.275
 Menopause (−) 1.252 0.369–3.941 0.704 1.614 0.104–46.371 0.736
 Tumor size (> 2) 6.235 × 107 0.822–0.822 0.073 3.108 × 109 1.662–7.5 × 10179 0.024
 Lymph node (+) 5.733 × 107 0.561–0.561 0.135 1.772 × 1010 1.806–unparsable 0.028
 Nuclear grade (3) 1.198 0.265–4.042 0.791 0.436 0.034–4.914 0.477
 Ki67 (> 14) 1.118 0.345–3.648 0.849 0.982 0.180–4.386 0.982
 Pathological response (non-pCR) 7.144 1.358–131.592 0.016 300.204 7.824–52,372.311 < 0.001
 Metastatic site (distant) 2.520 0.740–7.971 0.132 15.037 2.182–159.623 0.005
 Relapse-free survival (< 2 years) 2.175 0.647–9.825 0.219 0.165 0.012–2.177 0.160
TNBC (n = 20)
 Age (≤ 56) 0.936 0.291–3.018 0.910 0.578 0.011–20.101 0.759
 Menopause (−) 1.025 0.299–3.258 0.967 0.919 0.022–36.398 0.962
 Tumor size (> 2) 0.948 0.222–6.663 0.949 2.141 0.100–93.753 0.639
 Lymph node (+) 0.507 0.133–2.415 0.360 1.083 0.049–53.468 0.963
 Nuclear grade (3) 1.841 0.479–6.155 0.350 0.109 0.003–1.421 0.094
 Ki67 (> 14) 4.242 1.078–28.056 0.038 51.171 1.769–4346.194 0.020
 Pathological response (non-pCR) 2.110 0.547–13.871 0.303 1.813 0.045–56.645 0.733
 Metastatic site (distant) 1.569 0.486–5.070 0.442 13.318 1.021–540.473 0.048
 Relapse-free survival (< 2 years) 7.070 × 107 0.812–0.812 0.074 2.294 × 107 0.027–3.0 × 10289 0.454
  1. Values in parentheses are 95% confidence intervals
  2. CI confidence interval, pCR pathological complete response, TNBC triple-negative breast cancer