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Table 2 Univariate and multivariate analyses with respect to relapse-free survival in breast cancer subtypes

From: Significance of intrinsic breast cancer subtypes on the long-term prognosis after neoadjuvant chemotherapy

  Univariate analysis Multivariate analysis
Hazard ratio 95% CI p-value Hazard ratio 95% CI p-value
All breast cancer (n = 237)
 Age (≤ 56) 1.491 0.877–2.565 0.141 2.130 0.828–4.847 0.111
 Menopause (−) 1.220 0.709–2.074 0.467 0.703 0.310–1.802 0.439
 Tumor size (> 2) 1.679 0.738–4.830 0.236 1.509 0.640–4.436 0.372
 Lymph node (+) 1.720 0.904–3.620 0.102 1.829 0.950–3.880 0.072
 Nuclear grade (3) 0.899 0.427–1.713 0.758 1.452 0.642–3.064 0.356
 Ki67 (> 14) 0.553 0.325–0.945 0.031 0.548 0.300–0.991 0.047
 Pathological response (non-pCR) 2.046 1.143–3.891 0.015 1.886 1.005–3.746 0.048
Luminal (n = 93)
 Age (≤ 56) 1.223 0.537–2.871 0.631 5.007 0.988–20.715 0.052
 Menopause (−) 0.864 0.367–1.974 0.730 0.268 0.072–1.290 0.094
 Tumor size (> 2) 2.077 0.607–13.00 0.276 2.444 0.650–16.093 0.206
 Lymph node (+) 3.188 0.935–19.94 0.066 4.842 1.336–31.230 0.013
 Nuclear grade (3) 1.110 0.365–2.799 0.839 2.386 0.640–8.278 0.187
 Ki67 (> 14) 0.587 0.256–1.360 0.209 0.336 0.119–0.906 0.031
 Pathological response (non-pCR) 1.178 0.487–3.281 0.728 1.403 0.513–4.387 0.523
HER2-enriched (n = 43)
 Age (≤ 56) 2.124 0.559–8.614 0.262 1.059 0.050–9.029 0.962
 Menopause (−) 1.877 0.463–7.126 0.359 6.241 0.451–175.683 0.177
 Tumor size (> 2) 1.063 0.195–19.750 0.953 0.281 0.024–6.713 0.368
 Lymph node (+) 1.859 0.447–12.523 0.417 1.683 0.292–15.232 0.579
 Nuclear grade (3) 0.405 0.022–2.245 0.344 0.163 0.007–1.387 0.103
 Ki67 (> 14) 0.607 0.160–2.460 0.464 0.868 0.140–6.349 0.882
 Pathological response (non-pCR) 1.556 0.412–6.289 0.508 4.430 0.569–55.264 0.163
TNBC (n = 80)
 Age (≤ 56) 1.483 0.611–3.697 0.381 2.697 0.542–10.890 0.205
 Menopause (−) 1.318 0.515–3.195 0.550 0.539 0.136–2.660 0.416
 Tumor size (> 2) 1.155 0.333–7.263 0.844 0.643 0.160–4.296 0.596
 Lymph node (+) 1.065 0.411–3.282 0.904 0.625 0.214–2.083 0.421
 Nuclear grade (3) 1.098 0.314–2.999 0.868 2.909 0.679–11.523 0.143
 Ki67 (> 14) 0.488 0.202–1.250 0.130 0.486 0.150–1.518 0.213
 Pathological response (non-pCR) 4.251 1.557–14.857 0.004 5.013 1.612–19.386 0.004
  1. Values in parentheses are 95% confidence intervals
  2. CI confidence interval, pCR pathological complete response, TNBC triple-negative breast cancer