Skip to main content

Table 2 Univariate and multivariate analyses with respect to relapse-free survival in breast cancer subtypes

From: Significance of intrinsic breast cancer subtypes on the long-term prognosis after neoadjuvant chemotherapy

 

Univariate analysis

Multivariate analysis

Hazard ratio

95% CI

p-value

Hazard ratio

95% CI

p-value

All breast cancer (n = 237)

 Age (≤ 56)

1.491

0.877–2.565

0.141

2.130

0.828–4.847

0.111

 Menopause (−)

1.220

0.709–2.074

0.467

0.703

0.310–1.802

0.439

 Tumor size (> 2)

1.679

0.738–4.830

0.236

1.509

0.640–4.436

0.372

 Lymph node (+)

1.720

0.904–3.620

0.102

1.829

0.950–3.880

0.072

 Nuclear grade (3)

0.899

0.427–1.713

0.758

1.452

0.642–3.064

0.356

 Ki67 (> 14)

0.553

0.325–0.945

0.031

0.548

0.300–0.991

0.047

 Pathological response (non-pCR)

2.046

1.143–3.891

0.015

1.886

1.005–3.746

0.048

Luminal (n = 93)

 Age (≤ 56)

1.223

0.537–2.871

0.631

5.007

0.988–20.715

0.052

 Menopause (−)

0.864

0.367–1.974

0.730

0.268

0.072–1.290

0.094

 Tumor size (> 2)

2.077

0.607–13.00

0.276

2.444

0.650–16.093

0.206

 Lymph node (+)

3.188

0.935–19.94

0.066

4.842

1.336–31.230

0.013

 Nuclear grade (3)

1.110

0.365–2.799

0.839

2.386

0.640–8.278

0.187

 Ki67 (> 14)

0.587

0.256–1.360

0.209

0.336

0.119–0.906

0.031

 Pathological response (non-pCR)

1.178

0.487–3.281

0.728

1.403

0.513–4.387

0.523

HER2-enriched (n = 43)

 Age (≤ 56)

2.124

0.559–8.614

0.262

1.059

0.050–9.029

0.962

 Menopause (−)

1.877

0.463–7.126

0.359

6.241

0.451–175.683

0.177

 Tumor size (> 2)

1.063

0.195–19.750

0.953

0.281

0.024–6.713

0.368

 Lymph node (+)

1.859

0.447–12.523

0.417

1.683

0.292–15.232

0.579

 Nuclear grade (3)

0.405

0.022–2.245

0.344

0.163

0.007–1.387

0.103

 Ki67 (> 14)

0.607

0.160–2.460

0.464

0.868

0.140–6.349

0.882

 Pathological response (non-pCR)

1.556

0.412–6.289

0.508

4.430

0.569–55.264

0.163

TNBC (n = 80)

 Age (≤ 56)

1.483

0.611–3.697

0.381

2.697

0.542–10.890

0.205

 Menopause (−)

1.318

0.515–3.195

0.550

0.539

0.136–2.660

0.416

 Tumor size (> 2)

1.155

0.333–7.263

0.844

0.643

0.160–4.296

0.596

 Lymph node (+)

1.065

0.411–3.282

0.904

0.625

0.214–2.083

0.421

 Nuclear grade (3)

1.098

0.314–2.999

0.868

2.909

0.679–11.523

0.143

 Ki67 (> 14)

0.488

0.202–1.250

0.130

0.486

0.150–1.518

0.213

 Pathological response (non-pCR)

4.251

1.557–14.857

0.004

5.013

1.612–19.386

0.004

  1. Values in parentheses are 95% confidence intervals
  2. CI confidence interval, pCR pathological complete response, TNBC triple-negative breast cancer