Fig. 6

Pipeline for TPNAs discovery. Discovery of TPNAs is based on a two-round bioinformatics process. In the first round, TPNAs are identified to be different from related epitopes. In the second round, TPNAs are confirmed if no homology is found with any known epitope or if homology is found with pathogen-related epitopes. In the latter case, TPNAs are more efficient target of pre-existing T cell memory