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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Upregulation of miR-196b-5p attenuates BCG uptake via targeting SOCS3 and activating STAT3 in macrophages from patients with long-term cigarette smoking-related active pulmonary tuberculosis

Fig. 5

miR-196b-5p inhibited BCG uptake by macrophages. GFP tagged BCG was used to detect mycobacterial uptake by macrophages. The percentage and median fluorescence intensity (MFI) of GFP+ MDM (BCG uptake macrophages) among LCS-PTB patients, N-PTB patients and HV groups were detected by FCM analysis (a). And the BCG uptake by MDMs or differentiated U937 cells was detected after exogenously miR-196b-5p and anti-miR-196b-5p transfected (b). Data were presented as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001

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