Table 1 Model evaluation by LSSA and microarray analysis of mesothelioma cell line Mero-14
From: p53 modeling as a route to mesothelioma patients stratification and novel therapeutic identification
Source scenario in Mero-14 | Target scenario in Mero-14 | LSSA simulation | Total number of genes | Number of correct predictions | p-value of correct predictions | Number of small error predictions | Number of large error predictions |
|---|---|---|---|---|---|---|---|
TP53 wt without treatment | TP53 wt with Gem treatment | TP53 wt with DNA damage ON vs TP53 wt with DNA damage OFF | 199 | 149 (74.87%) | 4.33 × 10−33 | 48 (24.12%) | 2 (1.01%) |
TP53 wt without treatment | TP53 wt with etoposide treatment | TP53 wt with DNA damage ON vs TP53 wt with DNA damage OFF | 199 | 142 (71.36%) | 5.88 × 10−28 | 56 (28.14%) | 1 (0.5%) |