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Table 1 Model evaluation by LSSA and microarray analysis of mesothelioma cell line Mero-14

From: p53 modeling as a route to mesothelioma patients stratification and novel therapeutic identification

Source scenario in Mero-14 Target scenario in Mero-14 LSSA simulation Total number of genes Number of correct predictions p-value of correct predictions Number of small error predictions Number of large error predictions
TP53 wt without treatment TP53 wt with Gem treatment TP53 wt with DNA damage ON vs TP53 wt with DNA damage OFF 199 149 (74.87%) 4.33 × 10−33 48 (24.12%) 2 (1.01%)
TP53 wt without treatment TP53 wt with etoposide treatment TP53 wt with DNA damage ON vs TP53 wt with DNA damage OFF 199 142 (71.36%) 5.88 × 10−28 56 (28.14%) 1 (0.5%)