Fig. 5
From: A modified method for isolation of human cardiomyocytes to model cardiac diseases
Isolated atrial cardiomyocytes retain functional characteristics and are amenable to investigation. a Ca2+ transient of cardiomyocytes from heart failure patients and non-failing controls. b Oxygen consumption rate (OCR) of human failing cardiomyocytes and non-failing controls. Both c and d, responsiveness of myocytes to adrenergic stimulation. c For whole-cell patch clamp of ICa,L recording. d Ca2+ transient recording. The Ca2+ concentration was reported as the fluorescence normalized to the resting level (R = F/F0). n = 19 cells from 2 hearts. *P < 0.05, **P < 0.01, ***P < 0.0001, two-way ANOVA multiple comparisons’ test