Fig. 2
From: Large-scale in silico identification of drugs exerting sex-specific effects in the heart
Sexual differences of therapeutic evaluation for acebutolol and tacrine on heart. a Acute administration acebutolol, the change of heart rate was assessed. Treatment SHR with acebutolol for 4 weeks, the changes of heart rate (b) and blood pressure (c) were determined. Administration tacrine for 3 weeks, the heart rate changes (d), plasma cTNI level (e) and superoxide generation of heart by DHE staining were measured in mice, and metformin as a negative control for sexual differences. All data are present as mean ± SD. *P < 0.05; **P < 0.01 between two groups