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Table 1 Baseline characteristics of EV positive patients

From: CCR5del32 genotype in human enteroviral cardiomyopathy leads to spontaneous virus clearance and improved outcome compared to wildtype CCR5

Clinical parameters

EV persistence (n = 23)

EV clearance (n = 42)

EV persistence + IFN-β (n = 32)

ANOVA p value

Age (years ± SD)

54 ± 14

47 ± 15

50 ± 13

0.198

Male [n (%)]

18 (78.3)

26 (66.7)

22 (62.9)

0.379

NYHA I/II/III/IV (%)

8.3/66.7/16.6/8.3

16.0/56.0/24.0/4.0

4.2/54.2/37.5/4.2

0.451

EF at baseline (% ± SD)

45 ± 19

52 ± 18

51 ± 19

0.293

Endpoint of death [n (%)]

11 (47.8)

4 (9.5)

0 (0)

0.001

LVEDD (mm ± SD)

59 ± 10

54 ± 11

58 ± 7

0.121

LVEDS (mm ± SD)

46 ± 13

42 ± 12

41 ± 11

0.467

Palpitations (%)

27.8

54.3

34.6

0.122

Arrhythmias (%)

26.7

46.7

25.0

0.219

AVB (%)

11.1

6.7

8.3

0.870

RBBB (%)

11.1

9.7

4.2

0.677

LBBB (%)

11.8

22.6

8.7

0.346

Syncopies (%)

23.5

11.4

3.8

0.146

Diabetes (%)

11.1

18.4

19.2

0.635

Glycosides (%)

30.0

12.5

40.7

0.061

Diuretics (%)

42.9

59.1

70.0

0.297

Β-blocker (%)

43.8

21.9

57.7

0.686

ACE (%)

70.6

56.7

70.8

0.483

Cumarin (%)

25.0

12.9

29.6

0.292

Antiarrhythmics (%)

30.8

13.6

15.8

0.435

Pacemaker/ICD (%)

10/10

0/2.8

0/5.8

0.146

  1. IFN-β interferon-β, NYHA New York Heart Association Functional Classification, EF ejection fraction, LVEDD left ventricular end-diastolic diameter, LVEDS left ventricular end-systolic diameter, AVB atrioventricular block, RBBB right bundle branch block, LBBB left bundle branch block, ACE angiotensin-converting-enzyme, ICD implantable cardioverter-defibrillator