NPM1 alternative transcripts are upregulated in acute myeloid and lymphoblastic leukemia and their expression level affects patient outcome

Table 3 RNA-seq-based comparison of NPM1 transcript levels in AML and HV samples

Transcript	AML-T0		AML-T1		HV		AML-T0/HV TPM ratio
Transcript	Median level (TPM)	Contribution to the total NPM1 gene expression (%)	Median level (TPM)	Contribution to the total NPM1 gene expression (%)	Median level (TPM)	Contribution to the total NPM1 gene expression (%)	AML-T0/HV TPM ratio
NPM1.1	950.37	63.68	473.63	63.02	445.485	55.73	2.13
NPM1.2	55.36	3.71	18.14	2.41	24.655	3.084	2.25
NPM1.3	62.88	4.21	45.8	6.09	52.505	6.569	1.20
NPM1.4	1.09	0.073	0.43	0.057	1.46	0.183	0.75
NPM1.5	0.76	0.051	0.37	0.049	0.655	0.082	1.16
NPM1.6	0.71	0.048	0.5	0.067	0.53	0.066	1.34
NPM1.7	4.53	0.304	3.07	0.408	13.785	1.725	0.33
NPM1.8	0.4	0.027	0	0	0.385	0.048	1.04
NPM1.9	412.59	27.65	206.85	27.52	256.25	32.06	1.61
NPM1.10	0	0	0	0	0	0	–
NPM1.11	3.7	0.248	2.77	0.369	3.61	0.452	1.02
total	1492.39	100	751.56	100	799.32	100	–

ISSN: 1479-5876