Fig. 1

The schematic presentation of NPM1 gene structure and transcript variants. Exons are represented by numbered blocks. The black color marks the protein coding sequence. The red color indicates exons that are included in transcripts as partial sequences, lacking the 5′ or 3′ fragments of the exons present in the NPM1.1 transcript variant. The names of protein coding transcripts are written in dark red whereas the names of non-coding variants with retained introns/intron fragments (blue blocks) are written in black. The green arrows under transcripts indicate ddPCR primer positions. One of the NPM1.2-specific primers crosses the exon boundary (indicated by the dotted line linking exons 7 and 9)