Fig. 4
Transcriptional dialogue between HBx-transfected ARPE19-(HBx) and mock-transfected ARPE (mock) cells with and without UV irradiation. a Volcano plots of the sample with and without UV irradiation (mock vs. HBx). Standard selection criteria for identifying DE genes were established at log2 |fold change| ≧ 1 or ≤ − 1 and P < 0.05. b Number of upregulated or downregulated genes, compared with the expression levels, between mock-transfected and HBx-transfected cells with and without UVA/B irradiation (2 J/cm2). c Hierarchical clustering analysis of DE genes in mock-transfected cells versus HBx-transfected cells with and without UVA/B irradiation (2 J/cm2). The significantly DE genes following HBx infection (P < 0.05) from (b) were pooled and used to create heat maps. Genes are ordered in rows, and conditions are presented in columns. The red color indicates genes induced with UV irradiation versus without UV irradiation (fold change), and the green color denotes repressed genes